The organizing committee of the XIVth International Workshop on Molecular and Cellular Biology of Plasminogen Activation invites scientists from around the world with interest in plasminogen activation and other proteolytic systems to join us from the 4th – 8th of June, 2013 at the University of Notre Dame, Notre Dame, Indiana, USA.  The University of Notre Dame was founded in 1842 by the Catholic Congregation of the Holy Cross.  We were initially established as an all-male institution until 1972, when we first enrolled female undergraduate students.  Due to the Catholic character of the University, much of the campus architecture, such as the Main building’s Golden Dome topped by a statue of St. Mary, a replica of the Lourdes grotto next to St. Mary’s lake, a 134 foot tall (41 m) mosaic of Christ on the front of the Hesburgh library, the ornate Basilica of the Sacred Heart, and the numerous chapels, statuaries, and iconographies are reflective of this religious character.  Currently, the University is organized into 5 colleges and one professional school (Law).  Outside academia, Notre Dame is best known for its sports programs, especially football.  The University of Notre Dame lies east of Chicago directly across the southern tip of Lake Michigan (~ 90 miles, 144 km).  We are easily accessible from any major U.S. city.

The plasminogen activation system and related proteolytic systems are essential regulators of tissue remodeling events as well as regulation of cell functions through activation of cell signaling pathways.  Through early studies involving in vitro biochemical investigations, and more recently in vivo biological studies involving gene modified technology, the plasminogen activation pathway has been identified as a major participant in the regulation and progression of a number of clinically relevant human diseases.  These include cancer, cardiovascular diseases, neurological pathologies, and bacterial pathogenesis.  Therefore, topics of relevance to this meeting include but are not limited to the following:

  • Structure/function of plasminogen activators, receptors, and inhibitors
  • Plasminogen activation system in neurobiology, neuropathology, and stroke
  • Plasmin and plasminogen activators at the matrix metalloproteinase (MMP) interface
  • Plasminogen activator system in angiogenesis and tumor biology
  • Novel serine proteases and kringle-containing proteins
  • Plasminogen activation system in tissue remodeling and tissue repair
  • Plasminogen activation system in inflammation, infection, and host defense
  • Plasminogen activation system in stem cell biology and hematopoiesis
  • Cell signaling mechanisms in the plasminogen activation system
  • Novel therapeutics targeting the plasminogen system

This meeting has been held in alternate years since 1985, and is unique in that it is almost exclusively abstract-driven.  Therefore, the majority of the presentations are selected from submitted abstracts.  This allows for the emphasis of the meeting to be on new and unpublished research, which fosters productive interchange of ideas between attendees of the meeting.  This year we will have four State-of-the-Art presentations, which will highlight previous work in this area as well as examples of where this field is heading.  This is primarily for the benefit of new investigators in this area of research.  Posters will be displayed for the entire meeting to maximize opportunities for nurturing productive discussions and potential collaborations.

If you would like to be added to the e-mail list to receive announcements and additional information regarding the conference, please send your queries by e-mail to:

Please check this web site periodically for additional information.  Registration begins on December 1, 2012 and the abstract submission deadline has been extended to February 28, 2013.  Finally, there will be a number of fellowships for graduate students and postdoctoral fellows to offset a portion of the cost for attending this meeting.

We look forward to seeing you at Notre Dame.

On behalf of the Organizing Committee,
Francis J. Castellino and Victoria A. Ploplis